Author Archives: pkanold

New paper out: “Decreased Modulation of Population Correlations in Auditory Cortex Is Associated with Decreased Auditory Detection Performance in Old Mice“ or “There’s more to hearing issues in aging than the ear”

Heroic collaborative study by Kelson and Jonah is finally published. They looked at changes in how auditory cortex processes sounds embedded in noisy background and how this changes with aging. Read it here in the Journal of Neuroscience. JHU news here.

Phoenix rising

2 years ago we shut down the lab at UMD for COVID. Over the next year we packed up the lab and moved it to our new home at JHU. A lot of trips carrying stuff in our own cars, during COVID restrictions. Then came rebuilding of old setups and building of new setups with all the supply chain issues. This month marks the moment when the first papers and posters entirely generated in our new lab are being submitted. A momentous occasion that would have been impossible without the teamwork of the fantastic group of people that form the lab and that I have the privilege working with. Congratulations and thanks to: Binghan, Chih-Ting, Didhiti, Georgia, Ji, Jonah, Kate, Kelson, Lillian, Minzi, Travis.

New paper out showing sequential transmission of task-relevant information in A1

How is information about sound and behavioral choice integrated and processed in auditory cortex to lead to a behavior? Fantastic close collaboration with Babadi and Panzeri lab by Nik, Shoutik, and Loren shows that there are neurons encoding both sound and task information and that there is a sequential transmission of task-televant Information in A1. Read it here in Cell Reports.

New paper out! Impaired Hearing and Altered Subplate Circuits in Otoferlin deficient mice.

Otoferlin deficiency leads to impaired cochlear synaptic transmission and is associated with progressive hearing loss in adults. Didhiti and Ying wondered if loss of Otoferlin also had effects on cortical development. They found that spontaneous and sound-driven cortical activity in the first two postnatal weeks was impaired in Otoferlin knockout mice. Moreover, they found that in these mice subplate neurons received exuberant connections from within the cortex. Thus, otoferlin deficiency has a powerful influence on cortical connections and spontaneous activity in early development even before complete deafness. Therefore, peripheral activity has the potential to sculpt cortical structures from the earliest ages, even before hearing impairment is diagnosed. Read the full paper here in Cerebral Cortex.